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Anti-SOX11 Antibody
Monoclonal Antibody against HUMAN SOX11
1.0 mg/ml
Immunohistochemical staining of human mantle cell lymphoma shows moderate to strong nuclear positivity in tumor cells.
![Lane 1: Marker [kDa]_br/_Lane 2: Negative control (vector only transfected HEK293T lysate)_br/_Lane 3: SOX11 Over-expression Lysate (Co-expressed with a C-terminal myc-DDK tag (~3.1 kDa) in mammalian HEK293T cells, LY418895)](/thumb/10657/142x0/AMAb90502-wb-4.webp)
Product details
- Target protein: SRY (sex determining region Y)-box 11
- Target gene: SOX11
- Verified species reactivity: Human
- Interspecies information: Highest antigen sequence indentity to the following orthologs: MOUSE - ENSMUSG00000063632 (82%)RAT - ENSRNOG00000030034 (82%)
- Clonality: Monoclonal
- Clone ID: CL0143
- Isotype: IgG2a
- Host: Mouse
- Buffer: 40% glycerol and PBS (pH 7.2). 0.02% sodium azide is added as preservative.
Material Safety Data Sheet - Purification method: Protein A purified
- Notes: Gently mix before use. Optimal concentrations and conditions for each application should be determined by the user.
Current lot
- Unit size: 100µl
- Current lot: MAB-03504
- Concentration: 1.0 mg/ml
Applications
- Immunohistochemistry (IHC) recommended conditions
- Dilution: 1:200 - 1:500
- Retrieval method: HIER pH6
- Western Blot (WB) recommended conditions
- Working concentration: 1 µg/ml
Validation
- Immunohistochemistry (IHC) All IHC characterization data in 44 normal tissues and 20 cancers for AMAb90502 on the Human Protein Atlas
- Western Blot (WB)Validated in Western blot using relevant lysates (see Western blot application images above)
Target information
- Protein name: SRY (sex determining region Y)-box 11
- Gene name: SOX11
- Ensembl: ENSG00000176887
- Entrez: 6664
- UniProt: P35716
Shipping and storage
- Shipping: Normally shipped at ambient temperature.Storage: Store at +4°C for short term storage. Long time storage is recommended at -20°C.
References (4)
- SOX11 inhibitors are cytotoxic in mantle cell lymphomaClin Cancer Res , 2021 Jun 22; 27(16):4652-4663. Epub 2021 Jun 222021 Jun 22
- Plasma cell and terminal B-cell differentiation in mantle cell lymphoma mainly occur in the SOX11-negative subtypeModern Pathology , September 11, 20152015-09-11
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Researcher Contributions
Join the Explorer Program Are you using our products in an application or species we have not yet tested? Why not participate in the Explorer Program, and we will show your contribution here. If you would like to share your results with us, the Explorer Program offers a 25µl vial free of charge with your next order. Read more...
Alternative antibodies
Corresponding antigens
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Learn how we validate our antibodies, how we secure their reproducibility, and why we apply enhanced validation. Our antibodies are validated in IHC, ICC-IF, and WB.