Lineages are the pathways of development and differentiation of neurons and glial cells in the central nervous system. They are defined by the temporal and spatial relationship between the progenitors, early neuronal precursors, and the mature neurons that result from them. Neuronal lineages can be studied in the context of cell fate determination and the processes of development, such as migration, axon guidance, and synaptogenesis.
Download the "Neural Lineage Development Markers" white paper.
In this white paper, you can find our selections of PrecisA Monoclonals and TripleA Polyclonals validated in IHC, ICC-IF, and WB for tissue and cell analysis. All antibodies are paired with their specific PrEST Antigens.
Our brochure serves as a comprehensive resource for researchers featuring a selection of antibodies curated specifically for this area of study. Each antibody is accompanied by references to pertinent publications, facilitating researchers in accessing validated information and incorporating these antibodies into their experiments with confidence.
| Target | Protein name | Product ID | Validated applications | Homology (M / R) | PrEST control antigen |
|---|---|---|---|---|---|
| BMI1 | BMI1 proto-oncogene, polycomb ring finger | HPA030472Poly | IHC WB | 95% / 95% | APrEST77904 |
| CDH1 | cadherin 1, type 1, E-cadherin (epithelial) | AMAb90862Mono | IHC WB ICC-IF | 76% / 80% | APrEST86781 |
| CDH1 | cadherin 1, type 1, E-cadherin (epithelial) | HPA004812Poly | IHC | 76% / 80% | APrEST86781 |
| C21orf33 | chromosome 21 open reading frame 33 | HPA018517Poly | IHC ICC-IF | 90% / 88% | APrEST73887 |
| EGFR/ERBB1 | epidermal growth factor receptor | AMAb90819Mono | WB | 90% / 91% | APrEST78874 |
| FABP7/BLBP | fatty acid binding protein 7, brain | AMAb90595Mono | IHC WB | 89% / 90% | APrEST72726 |
| EGR1 | early growth response 1 | HPA029937Poly | ICC-IF | 93% / 94% | APrEST90701 |
| NES | nestin | AMAb90556Mono | IHC WB ICC-IF | 47% / 42% | APrEST70691 |
| NES | nestin | HPA006286Poly | ICC-IF | 47% / 42% | APrEST70691 |
| NOTCH1 | notch 1 | HPA067168Poly | ICC-IF | 75% / 75% | APrEST92698 |
| NR2E1 | nuclear receptor subfamily 2, group E, member 1 | HPA055642Poly | IHC | 99% / 99% | APrEST87723 |
| OCLN | occludin | AMAb90889Mono | IHC WB ICC-IF | 85% / 83% | APrEST83049 |
| OCLN | occludin | HPA005933Poly | IHC WB ICC-IF | 85% / 83% | APrEST83049 |
| PCGF5 | polycomb group ring finger 5 | HPA038349Poly | IHC ICC-IF | 95% / 93% | APrEST80382 |
| PROM1/CD133 | prominin 1 | HPA004922Poly | IHC WB | 57% / 60% | APrEST93420 |
| PROM1/CD133 | prominin 1 | AMAb91494Mono | IHC WB | 45% / 63% | – |
| RELN | reelin | HPA046512Poly | ICC-IF | 90% / 94% | APrEST91063 |
| SOX2 | SRY-box 2 | AMAb91307Mono | IHC WB ICC-IF | 99% / 99% | APrEST89511 |
| SOX10 | SRY-box 10 | AMAb91297Mono | IHC ICC-IF | 98% / 98% | APrEST92827 |
| Target | Protein name | Product ID | Validated applications | Homology (M / R) | PrEST control antigen |
|---|---|---|---|---|---|
| CSF3R/CD114 | colony stimulating factor 3 receptor (granulocyte) | HPA048086Poly | IHC | 58% / 60% | APrEST71845 |
| C21orf33 | chromosome 21 open reading frame 33 | HPA018517Poly | IHC ICC-IF | 90% / 88% | APrEST73887 |
| GLI3 | GLI family zinc finger 3 | HPA005534Poly | IHC | 74% / 76% | APrEST77454 |
| FABP7/BLBP | fatty acid binding protein 7, brain | AMAb90595Mono | IHC WB | 89% / 90% | APrEST72726 |
| FGF2 | fibroblast growth factor 2 | HPA065502Poly | IHC | 97% / 97% | APrEST94915 |
| GFAP | glial fibrillary acidic protein | AMAb91033Mono | IHC WB | 98% / 100% | APrEST85954 |
| GFAP | glial fibrillary acidic protein | HPA056030Poly | IHC WB ICC-IF | 98% / 100% | APrEST85954 |
| HES5 | hes family bHLH transcription factor 5 | HPA076164Poly | IHC | 96% / 96% | APrEST92568 |
| NOTCH1 | notch 1 | HPA067168Poly | ICC-IF | 75% / 75% | APrEST92698 |
| PAX6 | paired box 6 | AMAb91372Mono | IHC ICC-IF | 100% / 100% | APrEST84701 |
| PAX6 | paired box 6 | HPA030775Poly | IHC ICC-IF | 100% / 100% | APrEST84701 |
| PDGFD | platelet derived growth factor D | HPA066271Poly | IHC | 86% / 86% | APrEST91054 |
| SLC1A3/GLAST | solute carrier family 1 (glial high affinity glutamate transporter), member 3 | HPA037467Poly | IHC ICC-IF | 89% / 95% | APrEST79992 |
| SOX2 | SRY-box 2 | AMAb91307Mono | IHC WB ICC-IF | 99% / 99% | APrEST89511 |
| VIM | vimentin | AMAb90516Mono | IHC WB | 99% / 99% | APrEST85020 |
| VIM | vimentin | HPA001762Poly | IHC WB ICC-IF | 99% / 99% | APrEST85020 |
| Target | Protein name | Product ID | Validated applications | Homology (M / R) | PrEST control antigen |
|---|---|---|---|---|---|
| AP2A2 | adaptor-related protein complex 2, alpha 2 subunit | HPA043040Poly | WB ICC-IF | 94% / 94% | APrEST89460 |
| ACVR2A | activin A receptor, type IIA | HPA046997Poly | IHC | 100% / 100% | APrEST84534 |
| CD4 | CD4 molecule | AMAb90754Mono | IHC WB | 55% / 57% | APrEST86770 |
| CD4 | CD4 molecule | HPA004252Poly | IHC WB | 55% / 57% | APrEST86770 |
| DCX | doublecortin | HPA036121Poly | ICC-IF | 99% / 94% | APrEST90823 |
| EOMES/TBR2 | eomesodermin | HPA028896Poly | IHC | 96% / 96% | APrEST86712 |
| FZD4 | frizzled class receptor 4 | HPA074833Poly | ICC-IF | 95% / 99% | APrEST90414 |
| GAP43 | growth associated protein 43 | AMAb91664Mono | IHC | 85% / 85% | – |
| GAP43 | growth associated protein 43 | AMAb91665Mono | IHC | 85% / 85% | – |
| GAP43 | growth associated protein 43 | HPA013392Poly | IHC ICC-IF | 88% / 86% | APrEST72531 |
| GNL3 | guanine nucleotide binding protein-like 3 (nucleolar) | HPA036742Poly | IHC WB | 67% / 69% | APrEST87203 |
| GNL3 | guanine nucleotide binding protein-like 3 (nucleolar) | HPA036743Poly | IHC WB ICC-IF | 44% / 48% | APrEST87204 |
| HMMR | hyaluronan-mediated motility receptor (RHAMM) | HPA040025Poly | IHC WB | 59% / 62% | APrEST87348 |
| HMMR | hyaluronan-mediated motility receptor (RHAMM) | HPA061524Poly | ICC-IF | 82% / 69% | APrEST87348 |
| INA | internexin neuronal intermediate filament protein, alpha | HPA008057Poly | IHC WB ICC-IF | 83% / 84% | APrEST70159 |
| JAG1 | jagged 1 | HPA021555Poly | IHC | 94% / 93% | APrEST76170 |
| MLF2 | myeloid leukemia factor 2 | HPA010811Poly | IHC ICC-IF | 95% / 95% | APrEST71688 |
| MSI1 | musashi RNA-binding protein 1 | HPA064401Poly | ICC-IF | 98% / 100% | APrEST92457 |
| MSX1 | msh homeobox 1 | HPA063895Poly | ICC-IF | 92% / 71% | APrEST92415 |
| MSX1 | msh homeobox 1 | HPA073604Poly | IHC | 93% / 93% | APrEST93156 |
| NES | nestin | AMAb90556Mono | IHC WB ICC-IF | 47% / 42% | APrEST70691 |
| NES | nestin | HPA006286Poly | ICC-IF | 47% / 42% | APrEST70691 |
| NTN1 | netrin 1 | HPA056419Poly | IHC | 100% / 100% | APrEST85934 |
| NTN4 | netrin 4 | HPA049832Poly | IHC | 90% / 90% | APrEST85291 |
| NEUROD1 | neuronal differentiation 1 | HPA003278Poly | IHC WB | 98% / 97% | APrEST84787 |
| NOTCH1 | notch 1 | HPA067168Poly | ICC-IF | 75% / 75% | APrEST92698 |
| NOTCH2 | notch 2 | HPA048743Poly | IHC ICC-IF | 87% / 86% | APrEST88601 |
| NOTCH3 | notch 3 | HPA044392Poly | ICC-IF | 83% / 83% | APrEST76106 |
| OTX2 | orthodenticle homeobox 2 | HPA000633Poly | IHC | 100% / 100% | APrEST70417 |
| PAX3 | paired box 3 | HPA063659Poly | IHC ICC-IF | 92% / 92% | APrEST86379 |
| PAX3 | paired box 3 | HPA069000Poly | ICC-IF | 98% / 98% | APrEST92835 |
| S100B | S100 calcium binding protein B | AMAb91038Mono | IHC WB | 99% / 98% | APrEST73328 |
| S100B | S100 calcium binding protein B | HPA015768Poly | IHC WB ICC-IF | 99% / 98% | APrEST73328 |
| SEMA6A | semaphorin 6A | HPA031265Poly | IHC | 99% / 97% | APrEST78454 |
| SEMA7A | semaphorin 7A, GPI membrane anchor | HPA042273Poly | IHC | 85% / 87% | APrEST71580 |
| VIM | vimentin | AMAb90516Mono | IHC WB | 99% / 99% | APrEST85020 |
| VIM | vimentin | HPA001762Poly | IHC WB ICC-IF | 99% / 99% | APrEST85020 |
| Target | Protein name | Product ID | Validated applications | Homology (M / R) | PrEST control antigen |
|---|---|---|---|---|---|
| ATOH1/MATH1 | atonal bHLH transcription factor 1 | HPA049400Poly | ICC-IF | 90% / 87% | APrEST94695 |
| ASCL1 | achaete-scute family bHLH transcription factor 1 | HPA076307Poly | ICC-IF | 97% / 97% | APrEST95383 |
| FGFR1 | fibroblast growth factor receptor 1 | HPA056402Poly | IHC WB | 94% / 96% | APrEST86026 |
| FOXA2 | forkhead box A2 | HPA050505Poly | IHC ICC-IF | 96% / 82% | APrEST87559 |
| HES5 | hes family bHLH transcription factor 5 | HPA076164Poly | IHC | 96% / 96% | APrEST92568 |
| INA | internexin neuronal intermediate filament protein, alpha | HPA008057Poly | IHC WB ICC-IF | 83% / 84% | APrEST70159 |
| L1CAM | L1 cell adhesion molecule | AMAb91829Mono | IHC | 96% / 96% | – |
| L1CAM | L1 cell adhesion molecule | HPA005830Poly | IHC | 75% / 75% | APrEST74285 |
| LHX2 | LIM homeobox 2 | HPA000838Poly | ICC-IF | 100% / 100% | APrEST90527 |
| LHX2 | LIM homeobox 2 | AMAb91404Mono | IHC WB | 100% / 100% | – |
| MAP1B | microtubule-associated protein 1B | HPA022275Poly | IHC WB ICC-IF | 85% / 86% | APrEST86833 |
| MAP2 | microtubule-associated protein 2 | AMAb91375Mono | IHC WB ICC-IF | 91% / 90% | APrEST71545 |
| MAP2 | microtubule-associated protein 2 | HPA008273Poly | IHC ICC-IF | 96% / 96% | APrEST71546 |
| NEFL | neurofilament, light polypeptide | AMAb91314Mono | IHC WB ICC-IF | 97% / 99% | APrEST88940 |
| NEFL | neurofilament, light polypeptide | HPA014850Poly | IHC WB | 97% / 99% | APrEST88940 |
| NES | nestin | AMAb90556Mono | IHC WB ICC-IF | 47% / 42% | APrEST70691 |
| NES | nestin | HPA006286Poly | ICC-IF | 47% / 42% | APrEST70691 |
| NEUROD1 | neuronal differentiation 1 | HPA003278Poly | IHC WB | 98% / 97% | APrEST84787 |
| NGFR | nerve growth factor receptor | HPA004765Poly | IHC WB ICC-IF | 93% / 93% | APrEST70014 |
| NR4A2 | nuclear receptor subfamily 4, group A, member 2 | HPA000543Poly | IHC ICC-IF | 100% / 100% | APrEST76146 |
| RBFOX3/NeuN | RNA binding protein, fox-1 homolog 3 | AMAb91746Mono | IHC | 91% / 91% | – |
| RBFOX3/NeuN | RNA binding protein, fox-1 homolog 3 | HPA030790Poly | IHC ICC-IF | 93% / 94% | APrEST75751 |
| NKX2-2 | NK2 homeobox 2 | HPA003468Poly | IHC WB | 96% / 97% | APrEST84761 |
| NKX2-2 | NK2 homeobox 2 | AMAb91708Mono | IHC WB | 96% / 97% | APrEST84761 |
| NOG | noggin | HPA061318Poly | IHC | 100% / 100% | APrEST86333 |
| PAX3 | paired box 3 | HPA069000Poly | ICC-IF | 98% / 98% | APrEST92835 |
| PAX6 | paired box 6 | AMAb91372Mono | IHC ICC-IF | 100% / 100% | APrEST84701 |
| PAX6 | paired box 6 | HPA030775Poly | IHC ICC-IF | 100% / 100% | APrEST84701 |
| PDGFRA | platelet-derived growth factor receptor, alpha polypeptide | HPA004947Poly | ICC-IF | – | APrEST93915 |
| PDGFRB | platelet-derived growth factor receptor, beta polypeptide | HPA028499Poly | WB ICC-IF | 76% / 76% | APrEST77984 |
| POU3F2 | POU class 3 homeobox 2 | AMAb91406Mono | IHC WB ICC-IF | 100% / 100% | APrEST91088 |
| POU3F2 | POU class 3 homeobox 2 | HPA056261Poly | ICC-IF | 100% / 100% | APrEST91088 |
| SOX4 | SRY-box 4 | AMAb91378Mono | IHC ICC-IF | 78% / 78% | – |
| SOX4 | SRY-box 4 | HPA029901Poly | IHC ICC-IF | 100% / 39% | APrEST77513 |
| SOX21 | SRY-box 21 | AMAb91309Mono | IHC WB | 100% / 100% | – |
| SOX21 | SRY-box 21 | HPA064084Poly | ICC-IF | 96% / 37% | APrEST92430 |
| S100B | S100 calcium binding protein B | AMAb91038Mono | IHC WB | 99% / 98% | APrEST73328 |
| TBR1 | T-box, brain 1 | HPA078644Poly | IHC | 100% / 100% | APrEST91310 |
| EOMES/TBR2 | T-box, brain 2 / eomesodermin | HPA028896Poly | IHC | 96% / 96% | APrEST86712 |
| TH | tyrosine hydroxylase | AMAb91112Mono | IHC | 88% / 88% | APrEST87899 |
| TH | tyrosine hydroxylase | HPA014010Poly | ICC-IF | 91% / 89% | APrEST94048 |
| TUBB3 | tubulin beta 3 class III | AMAb91394Mono | IHC WB ICC-IF | 93% / 86% | – |
| TUBB3 | tubulin beta 3 class III | AMAb91395Mono | IHC WB ICC-IF | 93% / 86% | – |
| Target | Protein name | Product ID | Validated applications | Homology (M / R) | PrEST control antigen |
|---|---|---|---|---|---|
| Pan-neuronal | |||||
| DLG4/PSD-95 | discs large MAGUK scaffold protein 4 | HPA010122Poly | IHC | 99% / 99% | APrEST71165 |
| MAP2 | microtubule-associated protein 2 | AMAb91375Mono | IHC WB ICC-IF | 91% / 90% | APrEST71545 |
| MAP2 | microtubule-associated protein 2 | HPA008273Poly | IHC ICC-IF | 96% / 96% | APrEST71546 |
| NEFL | neurofilament, light polypeptide | AMAb91314Mono | IHC WB ICC-IF | 97% / 99% | APrEST88940 |
| NEFL | neurofilament, light polypeptide | HPA014850Poly | IHC WB | 97% / 99% | APrEST88940 |
| NEFM | neurofilament, medium polypeptide | AMAb91027Mono | IHC WB | 98% / 98% | APrEST76207 |
| NEFM | neurofilament, medium polypeptide | HPA023138Poly | IHC WB ICC-IF | 98% / 98% | APrEST76207 |
| RBFOX3/NeuN | RNA binding protein, fox-1 homolog 3 | AMAb91746Mono | IHC | 91% / 91% | – |
| RBFOX3/NeuN | RNA binding protein, fox-1 homolog 3 | HPA030790Poly | IHC ICC-IF | 93% / 94% | APrEST75751 |
| SYP | synaptophysin | HPA002858Poly | IHC WB | 83% / 37% | APrEST74355 |
| Glutamatergic | |||||
| GLS | glutaminase | HPA036223Poly | IHC WB ICC-IF | 6% / 98% | APrEST78979 |
| GRIN1/NMDAR1 | glutamate ionotropic receptor NMDA type subunit 1 | HPA067773Poly | IHC | 99% / 99% | APrEST94967 |
| GRIN2B/NMDAR2B | glutamate ionotropic receptor NMDA type subunit 2B | HPA069762Poly | IHC | 100% / 100% | APrEST88269 |
| SLC17A6/VGluT2 | solute carrier family 17 member 6 | AMAb91081Mono | IHC | 85% / 85% | APrEST80507 |
| SLC17A6/VGluT2 | solute carrier family 17 member 6 | AMAb91086Mono | IHC | 85% / 85% | APrEST80507 |
| SLC17A7/VGluT1 | solute carrier family 17 member 7 | HPA063679Poly | IHC | 94% / 94% | APrEST88047 |
| SLC17A7/VGluT1 | solute carrier family 17 member 7 | AMAb91041Mono | IHC WB | 94% / 94% | APrEST88047 |
| GABAergic | |||||
| GABBR1 | gamma-aminobutyric acid type B receptor subunit 1 | HPA050483Poly | IHC | 97% / 97% | APrEST83906 |
| GABBR2 | gamma-aminobutyric acid type B receptor subunit 2 | HPA013820Poly | IHC | 99% / 99% | APrEST72751 |
| GAD1/GAD67 | glutamate decarboxylase 1 | HPA048871Poly | ICC-IF | 97% / 97% | APrEST94691 |
| GAD1/GAD67 | glutamate decarboxylase 1 | AMAb91079Mono | IHC WB | 94% / 94% | APrEST79051 |
| GAD2/GAD65 | glutamate decarboxylase 2 | AMAb91048Mono | IHC WB | 84% / 88% | APrEST80257 |
| SLC6A1/GAT1 | solute carrier family 6 member 1 | HPA013341Poly | IHC WB | 98% / 98% | APrEST86858 |
| Dopaminergic | |||||
| SLC6A3/DAT | solute carrier family 6 member 3 | AMAb91125Mono | IHC | 85% / 85% | APrEST72519 |
| SLC6A3/DAT | solute carrier family 6 member 3 | HPA012763Poly | IHC | 86% / 86% | APrEST94046 |
| FOXA2 | forkhead box A2 | HPA050505Poly | IHC ICC-IF | 96% / 82% | APrEST87559 |
| LMX1B | LIM homeobox transcription factor 1 beta | HPA073716Poly | ICC-IF | 67% / 100% | APrEST93163 |
| NR4A2/Nurr1 | nuclear receptor subfamily 4 group A member 2 | HPA000543Poly | IHC ICC-IF | 100% / 100% | APrEST76146 |
| SLC6A2/NET | solute carrier family 6 member 2 | AMAb91116Mono | IHC | 93% / 93% | APrEST86811 |
| SLC6A2/NET | solute carrier family 6 member 2 | HPA076311Poly | IHC | 85% / 32% | APrEST94017 |
| TH | tyrosine hydroxylase | AMAb91112Mono | IHC | 88% / 88% | APrEST87899 |